Sentence examples for mutagenesis analyses of from inspiring English sources

Structure-guided mutagenesis analyses of FadR protein further suggested that the hydrophobic interaction amongst the three amino acids (W60, F74 and W75) might be essential for its DNA-binding ability by maintaining the configuration of its neighboring two β-sheets.

In addition, mutagenesis analyses of B. subtilis RNase H genes have shown that single-gene knockout mutants targeting the RNase HII or HIII genes exhibit normal growth, but that double-knockout mutants for both genes are unable to form viable colonies; this suggests that a functional overlap exists between RNase HII and HIII [ 31].

Previous structural and mutagenesis analyses of the cognate glutamine residues in Yersinia PTP and PTP1B have shown that Q506 is important for the optimal positioning of the nucleophilic water in the hydrolysis of the E-P intermediate, while Q510 plays an important role for both E-P formation and breakdown through a water-mediated hydrogen bonding network with the phosphoryl moiety.

A number of mutagenesis analyses on prokaryotic zinc, or iron-zinc CDFs [ 14, 29- 31] did not include the substitution of this highly conserved glycine residue (Table 1).

Future biochemical and mutagenesis analyses on the SLRP ear extensions will be necessary to elucidate any functional role of these structures in ligand recognition and binding.

Site-directed mutagenesis analyses, production of chimeric neurotrophins and mimetic peptides have highlighted specific and variable regions among neurotrophins that are important for the binding specificity and/or activation of their cognate Trk receptors [for reviews, see [17], [18], [19]].

In this study, Hicks et al. first performed genetic mutagenesis analyses and NMR structural analyses of PhoQ PD to reveal the mechanism of PhoQ sensing of acid pH.

Now the crystal structure of A3C and homology models for A3F and A3DE, together with mutagenesis analyses, allow the identification of their interaction interface with Vif, which is different from a previously implicated region in A3G.

The results of site-directed mutagenesis analyses carried out on four CDF transporters ([14, 23, 29-31] and present study) are reported with the corresponding topological position.

Through extensive domain-swapping and mutagenesis analyses, we found that 15 membrane-proximal residues of the mIgG tail conferred enhanced oligomerization.

Bioinformatics and mutagenesis analyses have demonstrated that the best-characterized member of the KCTD family, KCTD11/REN, is expressed as two alternative variants, sKCTD11 and lKCTD11.