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Our evidence suggests that IL-1β must unfold or be held in an unfolded state to promote membrane translocation and that a complex sorting signal in the mature portion of IL-1β interacts with HSP90 to deliver the chaperone and its cargo to a site on a phagophore precursor membrane where the mature species is translocated.
These experiments must unfold in divided societies with weak economies and unresolved — perhaps never to be resolved — tensions between mosque and state.
Yet Einstein also believed that the world was ultimately rational, that events within it must unfold according to the logic of cause and effect.
"This process must unfold according to the needs of Iraqis - neither hurried nor delayed by the voices of other parties," he said.
In fact, though they will not say so publicly, some administration officials say that Pakistan may be where the next phase of the war must unfold.
The pitfall to stabilising local interactions is to present hurdles to the rapid and efficient folding of small proteins down a smooth folding funnel by trapping partially folded or misfolded states that must unfold or rearrange before refolding.
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A user must simply unfold the inhaler, which pierces a foil pouch that holds dry powder, and breathe in.
Having reached K2's summit myself in 1993, I know that many details must still unfold before we can understand this tragedy.
It is clear that implementation of family strengthening programmatic activities must either unfold alongside or build upon efforts to economically strengthen families.
The biological relevance of these studies is with respect to the dynamics of channels: their requirement of flexibility for ion channel activity means that they must not unfold easily when subjected to conformational stress.
In other words, the native β-hairpin must partially unfold to relax into a flat β-sheet unit, a structure required for the growth of the aggregate nucleus into long fibrils.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com