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A study aiming at comparing NISS and ISS must be prospective in nature and designed for coding of all injuries.
The evaluation of this revised strategy for the use of second-look surgery must be prospective and thorough.
The discrepancy in these reports highlights the challenges to the evaluation of sensitivity and specificity of imaging modalities in patients with early SpA because the gold standard for diagnosis is radiographic sacroiliitis, which means that such evaluations must be prospective to allow time for radiographic abnormalities to appear.
For example, the Food and Drug Administration FDAA) recently produced some guidelines for industry 7 that include an explanation of how adaptive designs must be prospective: "The term prospective here means that the adaptation was planned (and details specified) before data were examined in an unblinded manner by any personnel involved in planning the revision".
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The study must be a prospective clinical trial providing race specific data on blood pressure lowering during treatment with ACEI.
Results must be confirmed by prospective and multicenter studies.
Of utmost importance, the "Oncoscore" must be validated in prospective studies and cannot be used, in its form without external validation, for individual decision making.
Initially, a letter of appointment must be sent to prospective postdoctoral candidates from this office; it is imperative that the offer letter come directly from here, rather than from a department or a primary investigator.
Among these factors, patients' job satisfaction and job recognition largely contribute to this dimension and must be considered in prospective studies.
Although these findings must be confirmed in prospective studies, they are very promising.
These findings must be confirmed by prospective studies of larger numbers of patients.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com