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It is thought that the old centromere must be inactivated because dicentric chromosomes are not viable.
In most of these, simply adding a normal copy of the gene will not help; instead, the mutated gene must be inactivated.
The system must be inactivated (the umpire pushes a button on the control box) immediately after a good serve so the ball, racket or feet do not trip the beams again, triggering more beeps.
The gene p53 has been fashioned as the guardian of the genome and as prototype of the tumour suppressor gene (TSG) whose function must be inactivated in order for tumours to develop.
Our hypothesis was that under selective pressure in vivo the introduced TSG must be inactivated in growing experimental (xenografted) tumors (by deletion, mutation, promoter methylation) as in the naturally growing tumors.
The ability to functionally lesion brain regions, or cell types, in a rapidly reversible fashion opens up a large class of experiments in which specific neuron populations must be inactivated for precise, sub-second durations during a task.
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Aurora must also be inactivated or degraded when the cell proceeds in G1 phase.
In order for thrombin to be inactivated by antithrombin, not only must heparin be bound to antithrombin but it must also accumulate on thrombin.
Transdermal drug delivery must ensure that the drug will not be inactivated on the skin's surface or even during the penetration process (Langer 2004).
After the drug is gone, that memory should be inactivated".
Instead, the reversion needs to be inactivated.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com