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Where QOL assessment is appropriate however, inclusion of a QOL measure must be hypothesis driven and an integral part of the clinical development programme rather than an added afterthought [ 5].
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For example, The Human Genome Project was considered by many at the time to be a serious break with the notion that proper biological research must be hypothesis-driven.
While it is given that cohorts such as other NIH-funded research endeavors must be hypothesis-driven, it is instructive to briefly review the origin of several major cohorts that have helped shape public health in the United States and internationally.
18 As such, it must be considered hypothesis generating.
In addition, the qualitative interviews must be considered hypothesis generating.
It must be considered hypothesis generating, and thought provoking.
However, the design of the present study is such that these observations must be considered hypothesis generating.
These analyses were all conducted as secondary objectives, and therefore these results must be considered hypothesis generating.
However, while causality cannot be proven by these data - they must be considered hypothesis generating - the findings of this investigation suggest that critical care teams should attempt to avoid even modest degrees of hypoglycemia in their patients.
As our results must be considered hypothesis generating, randomized controlled trials are required to evaluate whether targeting these levels as early resuscitation endpoints can improve mortality in cardiogenic shock.
Finally, we acknowledge that the observational nature of this investigation mandates that its conclusions must be considered to be hypothesis generating, rather than proof of causality.
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