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Applying this data to a 3D model of an equivalent porous medium showed that the plume at the bottom of the subsurface aquifer must be downstream from the well.
Previous chronic treatment with different antidepressants prevented the up-regulation of glutamate release in P/FC, by a mechanism that must be downstream of SNARE complex accumulation.
Because all drugs employed did not block either elevation of corticosterone or accumulation of SNARE complexes, the dampening action of the drugs on glutamate release must be downstream of these processes.
Since compounds 4 and 8 do not reduce sorbitol by inhibiting AR, their delay of cataract formation must be downstream of the osmotic effect that induces GRP78/Bip and generates ROS.
Secondly, the SECIS elements were used to inform gene prediction algorithms to predict i-ORFs, of which a suitable SECIS element must be downstream [ 14].
HDACs do not have the enzymatic capacity to alter DNA lengths, so it was clear that there must be downstream targets.
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If Qd does lie causally upstream from a forking path common cause of Qa and Qb, then there must be a downstream path P′ from Qd to Qb.
A multi-path backscattering might produce additional peaks in the periodogram which do not correspond to true targets, but this is a common problem of all radar systems and must be treated downstream in the processing chain.
To explain this conundrum, AGB1 must be acting downstream of AtGPA1.
Given that IRF4 and Blimp-1 can be expressed in the absence of XBP-1, XBP-1 must be placed downstream of both of these factors, an observation consistent with earlier data showing that IRF4 and Blimp-1 increase xbp-1 transcription (Shaffer et al, 2002; Klein et al, 2006).
Nevertheless, there must be divergent downstream signaling pathways activated following a rise in PIP3 to explain the opposing PI3K-dependent electrical responses seen in some POMC neurons to leptin and insulin, which results in either KATP channel activation (hyperpolarization) or the activation of an, as yet, ill-defined putative nonselective cation channel (depolarization).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com