Mg2+ administration provokes muscle weight increase on the operated side.
In addition, its upregulated expression in skeletal muscle correlated with slow muscle fibre formation and low muscle weight increase in the present study.
It is noted, however, that differences between 6 and 32 months are not continuous, linear changes since body weight and some muscle weights increase through late middle age (Lushaj et al. 2008).
Muscle weight was increased after A. awamori feeding.
In this study we have found that body weight and breast muscle weight were increased by AA and FOS.
Skeletal muscle mass and muscle mass as ratio to body weight increased at 12 months of age compared to 6 months of age (p < 0.001, Table 1) and decreased at 18 (p < 0.001) and 24 (p < 0.001) months of age compared to 12 months (Table 1).
An interesting observation from this work is that even though skeletal muscle weights were increased following CRF2R activation, increases in absolute body mass were not consistently observed.
This result suggests that EGb 761 affects body and muscle weight by increasing the muscular mass and, thus, reversing toward the juvenile values the age-related decrease of the ratio of muscle v/s body weight.
Conversely, overexpression of the active MSTN peptide in muscle results in low muscle weights and increased fat mass [13], suggesting that processing of MSTN may play a role in energy partitioning between protein and fat, counteracting muscle-wasting disorders that are prevalent in many disease states including diabetes.
Moreover, the rank order of magnitude of these increases correlated with the rank order of expression levels of the transgene; in the highest-expressing line, Z116A, muscle weights were increased by 57 81% in females and 87 116% in males compared to wild type mice.
