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This reduced missing muscle weakness values to 74 (7%).
For assessing muscle weakness, values <20 kg and <30 kg were considered for female and males, respectively [ 24].
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The mean value of TwPdi in our case series was 11.5 ± 3.9 cm H2O, which is similar to the previous two case series [ 19, 20] and clearly supports and underscores the fact that these patients have severe respiratory muscle weakness, as values in healthy volunteers have been reported to average from 28 to 38 cm H2O [ 20, 22].
Values that are less negative do not prove muscle weakness (poor positive predictive value), as this method depends on cooperation and lung volume.
Values that are more negative virtually exclude significant inspiratory muscle weakness (good negative predictive value).
Again, using relative grip strength estimates is a more robust method to assess muscle weakness; an absolute strength value is less meaningful because it obviously depends on the subject's stature.
[CTG] expansion size did not correlate to the presence or absence of ECG abnormalities or degree of muscle weakness as assessed by MRC values.
Furthermore, the predictive value of muscle weakness for fatigue severity was determined, together with that of pain and physical activity.
One male SSc patient however, had muscle atrophy with symmetric proximal and distal muscle weakness; his serum CK (normal value <190 U/L) was 1570 U/L.
Denominators accounting for missing values: Charlson n = 139; slow gait n = 64; muscle weakness = 87; weight loss n = 159.
These include elevated serum values of muscle enzymes, pathologic muscle biopsy, pathologic electromyography, proximal and symmetrical muscle weakness, and for dermatomyositis characteristic skin symptoms.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com