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This is in accordance with the normal dimension of myocytes and the preserved muscle volume observed.
The increase in skeletal muscle volume observed at E13.5 may be indicative of increased lipogenesis, while the localized differences indicated by the deformation analysis within internal organs could arise from inhomogeneous energy supply to those sub-regions, or their preference for a different metabolic fuel during their growth.
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These muscle shrinkage values are much smaller than the up to 70%% change in volume observed in mouse hearts when a much higher concentration I2KI (as Lugol's iodine) was used with a shorter staining duration [ 12].
To ascertain the usefulness of this novel method of volumetry of diseased muscle, we prospectively followed 14 patients with muscular dystrophy and observed progressive decreases in net muscle volume over 4 years.
Muscle volume reduction following the injury of long head of biceps was observed, but fatty infiltration was infrequently seen on these follow-up MR imaging [45].
6, 7 Although the previous studies observed change in muscle fiber size resulting from running, the whole muscle volume or CSA has not been investigated.
Our study also shows that soccer induced a similar increase in the muscle volume of both sides of RA (28 and 25%) which contributed to maintain the side-to-side proportions observed in non-active controls (ratio 0.99).
By contrast, we believe that tamoxifen-induced muscle atrophy observed in WT mice is likely species-specific as, to our knowledge, alteration of muscle volume has not been reported in human, not even in breast cancer patients having been on tamoxifen for several years.
A higher muscle volume laterally and centrally can theoretically produce higher muscle forces, which may explain why more fibrocartilage was observed at these regions compared to the medial side.
In the physically mature rugby players assessed here, a comparatively strong association is observed; highlighting that once fully developed, changes in neck circumference are likely to reflect the muscle volume of the individual.
An inverse relationship was observed between muscle length starting from the inter-discal L1-L2 spand and the mean difference in the muscle volume of the non-dominant side between soccer players and controls adjusted for age, the length of each segment and BMI (r = −0.71, P<0.05) (Fig. 4).
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