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The description of a muscle trauma model should therefore not solely include morphological but also mechanical data.
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Experimental research on skeletal muscle trauma requires reliable animal models.
Our trauma model allows investigation of muscle regeneration after a standardized injury to muscle fibers.
Direct muscle trauma is a common and disabling clinical problem.
Severe injuries to the extremities often result in muscle trauma and, in some cases, significant volumetric muscle loss (VML).
After muscle trauma, blood vessels rupture induces tissue hypoxia at the injury site (Jarvinen et al. 2005).
The advantage of the trauma model presented here is that with the greatest degree of possible myofiber injury without denervation injury, the effects of new therapies for skeletal muscle trauma can be analyzed with the lowest bias in the intrinsic regeneration capacities of the muscle itself with the maximum range for a possible therapeutic effect.
The exercise protocol, that involved eccentric muscle contraction, also caused some muscle trauma, associated with over-exertion, leading to inflammation.
These techniques allow a lower muscle trauma and help to a quicker postoperative recovery.
The Trauma Model incorporates measures of isolation and time to a trauma service, social vulnerability, and a risk of trauma measure as variables [ 24].
The concomitant muscle trauma may facilitate the passage of MyoD-lineage cells through injured fascial compartments to the fracture site.
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