In a large genome-wide study of muscle tissue expression, we found that some genes exhibited a bimodal distribution of RNA expression, in contrast to what is usually assumed in studies of a single healthy tissue.
Nearly all of the confirmed bimodally expressed genes and half of the entire bimodal set had highly significant (unadjusted p < 10-8) associations between muscle tissue expression and SNP genotype (Table 5 and Additional file 5), and were hence expression quantitative trait loci (eQTL).
For example, adipose tissue gene expression has been found to show more differences between T2D and healthy control than muscle tissue gene expression.
However, in adult carcass, which consists mainly of muscle tissue, the expression of Cox7a isogene CG34172 predominates.
For example, of the 25 differentially expressed genes classified in muscle tissue development, the expression of 15 genes, including insulin-like growth factor binding protein 5 (IGFBP5; 8.57-fold change), was upregulated by PC.
Here we uncover the role of skeletal muscle genes (SMGs) expression in hypersusceptibilty to infection that follows severe trauma and show that the presence of highly virulent P. aeruginosa in injured skeletal muscle tissue restricts SMG expression.
The following effects of mechanical injury of the muscle tissue on the expression of the genes IL-1β, IL-8, TGF-β and TLR-3, 5 m, 9 and 22 at the time points 4, 8 and 24 hours post injury (p.i). is shown in figure 4 A-F.
In skeletal muscle tissue), the mRNA expression pattern was similar to the one observed in spinal cord.
Interestingly, genes encoding mitochondrial proteins represent the major group of genes that are misregulated both, in our model, and in muscle tissue where salm expression was silenced [ 46] (Additional file 12: Table S12).
Moreover, we have shown for the first time that conventional immunosuppressive treatment led to a significant downregulation of COX-2 in myositis muscle tissue, while the expression of mPGES-1 and COX-1 remained unchanged.
To summarize, in the basal state of skeletal muscle tissue, the protein expression of TRX-1 was significantly lower while that of HSP90 was significantly higher in the T2D patients than in the IGT subjects.
