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Click on a gene's description to view its network relationships with genes known to be involved in "muscle tissue development".
Click on a gene's description to view its network relationships with genes known to be involved in "striated muscle tissue development".
Click on a gene's description to view its network relationships with genes known to be involved in "skeletal muscle tissue development".
GSEA analysis also showed a consistency of the C2C12 data (Supplementary Table 3): that a rate change phenomenon was observed in genes other than those related to skeletal muscle differentiation (GO 1901861, Regulation of muscle tissue development, NES = 2.07).
The receptors involved in adhesion included the αvβ5 to vitronectin, the α5β1 to fibronectin and the α2β1 to collagen I. Identification of the specific receptors used to adhere to these polymers clarifies why smooth muscle tissue development differs on these scaffolds, and may allow one to design tissue formation by controlling the surface chemistry of tissue engineering scaffolds.
Histological analysis of PC-CCL20 tumors demonstrated an invasion of tumors to adjacent muscle tissue, development of necrosis that can be associated with rapid tumor growth, and massive aberrant vascularization of tumors.
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Aside from the regulatory, cultural and engineering challenges to selling engineered meat, Gabor Forgacs explains in this TED Talk, where he eats a bite-sized morsel of printed pork, that Modern Meadow is still fine-tuning the fat content and electrical stimulation of muscle tissue during development that are necessary to make lab-grown meat taste like farm-raised meat.
In conclusion, all three genes play roles in skeletal, muscle and tissue development.
Muscle tissue morphogenesis and development, cell differentiation and development, regulation of muscle contraction and developmental process were enriched significantly in early embryo development.
These changes could have important implications on food animal production especially if these perturbations impact muscle and adipose tissue development.
Interestingly, PC upregulated the expression of many genes classified in muscle and skeletal tissue development, including IGFBP5.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com