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Horses, in particular Thoroughbreds, have a very high muscle mass to body weight ratio (55%) compared to other mammalian species (30 40%) [6] and the Thoroughbred genome contains evidence for selection for muscle strength phenotypes [7].
The presence of genes for α-actinin, α-actin and its chaperon, CCT, and four of the six sarcoglycan complex genes as well as an overrepresentation of focal adhesion complex genes in positively selected regions in Thoroughbred suggest that selection for muscle strength phenotypes has played a major role in shaping the Thoroughbred.
Recent research indicates that PPP1CC is a positional candidate locus for skeletal muscle strength phenotypes [ 15].
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Associations of selected SNPs with a muscle strength phenotype were also explored.
Moreover, we have previously determined that focal adhesion molecules may represent targets for recent artificial selection in the Thoroughbred and therefore may be critical to the development of the muscle strength phenotype for which Thoroughbreds are renowned [ 55].
Pargyline, a monoamine oxygenase inhibitor, reduced reactive oxygen species accumulation along with a beneficial effect on dystrophic phenotype and muscle strength in mouse muscular dystrophy models, including mdx mice.
The phenotypes examined were baseline muscle strength and muscle, fat, and bone volume and their response to RT. FAMuSS participants were 1300 young (24 years), healthy men (42%) and women (58%) that were primarily of European-American descent.
We found a significant overrepresentation of sarcoglycan complex (11.1-fold enrichment; P<0.05) and focal adhesion pathway (1.9-fold enrichment; P<0.01) genes highlighting the role for muscle strength and integrity in the Thoroughbred athletic phenotype.
Geusens et al. showed that the presence (allele bb) or absence (allele BB) of a restriction fragment (BsmI) may determine muscle strength; that is, subjects with the bb phenotype had 23% higher muscle strength in the quadriceps than those with the BB phenotype [ 28].
Based on the observations presented here, it can be concluded that a 12-week progressive RT program besides promoting increases in isokinetic muscle strength induces beneficial alterations on metabolic syndrome-related phenotypes in postmenopausal women.
Based on the observed results, it can be concluded that a 12-week progressive RT program, besides increasing isokinetic muscle strength, induces beneficial alterations on metabolic syndrome-related phenotypes in postmenopausal women.
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