He found that generalised joint hypermobility was associated with "lower muscle strength, lower submaximal exercise capacity, and decreased functional walking distance" for patients from both schools.
Skeletal muscle strength, lower extremity function, and mobility are each associated with disability risk in older adults (Guralnik et al., 1994; Newman et al., 2006; Puthoff & Nielsen, 2007).
Decreased muscle strength, lower muscle quality, and accelerated loss of muscle mass, especially in the lower extremities, have all been documented in individuals with diabetes (21).
For instance, patients with chronic heart failure who perform regular moderate exercise have increased functional capacity, greater muscle strength, lower mortality and greater quality of life compared to non-exercising controls [ 33- 35].
Therefore, identification of mechanisms underlying muscle strength, lower extremity function, and mobility will be important for addressing the growing challenge that health care will face with physical disablement in the expanding aging population.
Studies found that age, decline in mobility, malnutrition, decreased muscle strength, lower bone mineral density, abnormal vitamin D metabolism, abnormal parathyroid hormone level, cardiovascular disease, and pneumonia contributed to mortality after hospitalization in hemodialysis subjects [ 15, 16, 19, 24].
It's important to establish an exercise regimen because physical activity offers many health benefits, including decreasing blood pressure, increasing muscle strength, lowering blood fat levels (cholesterol and triglycerides), improving sleep, decreasing stress, increasing insulin sensitivity and helping control body weight.
Previous studies have shown that endurance athletes such as long-distance runners have higher frequencies of this mutation, whereas sprinters and athletes in other sports that require quick muscle strength have lower frequencies.
The authors used 2 tests for muscle strength of lower limbs assessment.
Both MM patients started with muscle strength values lower than normal (13% in patient 1 and 58% in patient 2).
36 Thus, our results indicate that increasing muscle strength in lower limbs can improve older individuals' ability to successfully perform daily tasks.
