Resistance exercise in particular seems to activate a muscle stem cell called a satellite cell.
Satellite cells (SC) are skeletal muscle stem cell located between the plasma membrane of myofibers and the basal lamina.
Another recent study demonstrated that the E3 ligase TRIM32 is expressed in the skeletal muscle stem cell lineage of adult mice; myogenic differentiation is disrupted and muscle regeneration is delayed in the absence of TRIM32 (Nicklas et al., 2012).
A major limitation to the study and clinical utility of satellite cells is that upon removal from the muscle fiber and plating in traditional plastic tissue culture platforms, their muscle stem cell properties are rapidly lost.
We conclude that reciprocal control of antagonistic Wnt signaling pathways by Rspo1 in muscle stem cell progeny is a key step ensuring normal tissue architecture restoration following acute damage.
This study examined IL-6 signaling in the context of muscle stem cell proliferation induced by MLC.
Collectively, these results identify a novel role for Ang II in the regulation of skeletal muscle growth and muscle stem cell function.
Such a stem cell should be systemically-deliverable, contribute to widespread muscle regeneration and ideally, functionally reconstitute the muscle stem cell pool.
Since PKD2 was found be the major isoform expressed during the initial stages of differentiation at the level of gene expression, we focussed on the role of this isoform in the process of muscle stem cell differentiation.
Different muscles may contain either different numbers, or types, of different muscle stem cell populations, but experiments comparing the same stem cell derived from different human muscles have not been done.
In the present study, we used a mouse myoblast cell line (C2C12) as an in vitro model to investigate the role of PKDs, in particular PKD2, in muscle stem cell differentiation.
