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The mesencephalic trigeminal nucleus receives proprioceptive sensory inputs via the trigeminal nerve from the masseter muscle spindle and the periodontal ligaments during mastication [ 97].
The mechanism of pain and muscle engorgement may be related to abnormal firing of α motor neurons due to miscommunication with the muscle spindle and the Golgi tendon organ.
Local muscle fatigue has been shown to be responsible for increased muscle spindle and decreased Golgi tendon organ afferent activity, 28 but as yet this has not been demonstrated conclusively.
Thus our conceptual framework centred on the muscle spindle and John, who had access to human intercostal muscle biopsies, subsequently used the same experimental rig to examine the muscle spindles in these muscles, and provided the first account of their activation in his in vitro preparation (Tom Sears; Supplementary material B8 ).
In the context of human standing, continuous reflexive systems, incorporating muscle spindle and Golgi tendon organ feedback, provide tonic equilibrium joint moments through tonic stretch reflexes (Sherrington 1947) and provide partial dynamic stabilisation of the unstable mechanical system (Marsden et al. 1981; Fitzpatrick et al. 1996; Loram and Lakie 2002a, b).
We estimated the diameter and determined the number of intrafusal fibres per muscle spindle and observed that the co-IgNrg1 or Bace1 mutations resulted in increased proportions of muscle spindles characterized by a small diameter (<30 μm; Figure 6B) and few intrafusal fibres (≤3 fibres/spindle; Figure 6D).
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Granit then turned his attention to the study of the control of movement, specifically the role of muscle sense-organs called muscle spindles and tendon organs.
These mechanoreceptors are known as muscle spindles and consist of the stretch-sensitive endings of one or more neurons attached to a region near the centre of a modified muscle fibre.
Signals from stretch receptors (i.e., muscle spindles and tendon organs) end in parts of laminae V, VI, and VII; collaterals of these fibres associated with the stretch reflex project into lamina IX.
Low-frequency forces are sensed by SA receptors [41], and by Golgi organs, muscle spindles, and joint capsule receptors in the muscles, tendons, and joints.
As mentioned in the Introduction, thin axons have already been described within muscle spindles and other mechanoreceptors including tendon organs, Ruffini endings and Meissner corpuscles [25], [26].
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