Sentence examples for muscle polyQ models from inspiring English sources

Treating C. elegans muscle polyQ models with hydroxylamine, icariin and celecoxib derivatives (NG-094, icariside II and OSU-03012, respectively) ameliorated polyQ-mediated protein aggregation and protected against polyQ proteotoxicity [48 50] (Table 1; Figs. 1, 2).

The list of genes in the intersection between the polyQ models (AR97Q and AR113Q) is reported in Table 2.

Use of RNAi screens in Drosophila cell lines with similar huntingtin polyQ models identified 21 [ 21] and 126 [ 22] regulators respectively.

Elevated expression of HMGBs protects against polyQ-induced neurotoxicity in primary neurons and in a Drosophila polyQ model [15].

The aggregation propensity of polyQ model peptides increases with Gln repeat length.

This is the first report of a polyQ model generated by en masse expansion.

In contrast, a neuroprotective effect on a polyQ model of neurodegeneration remained associated with sir-2.1 overexpression [ 41].

Like the polyQ model systems where molecular chaperones helped protect against cytotoxicity, overexpression of the molecular chaperone Hsp70 reduced cytotoxicity in C. elegans.

In doing so, httNT facilitates a distinct multistage aggregation pathway that features α-helix-rich oligomeric species (in contrast to polyQ model peptide aggregation).

A larger drop in strain energy (40%) was observed from one-muscle to 2 4 muscle models, and a ∼25% drop from 2 4 muscle models to 5 7 muscle models.

Moreover, overexpression of wild-type AR in muscle replicates polyQ disease in mouse models of SBMA, suggesting that an expanded polyQ tract is not the only determining factor, and expression levels of specific proteins and unique cellular contexts may also be important factors of toxicity.