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These studies demonstrate the important role of SelN for muscle organization during early development.
(CUG 60 RNA did not appreciably affect muscle organization.
Roles for CELF proteins in normal skeletal muscle organization and composition have been suggested by previous studies in other animal models.
These results are consistent with our data that suggest that CELF activity is required for muscle organization, but not overall muscle mass.
Nonetheless, even these small changes in CELF-mediated splicing regulation were sufficient to alter muscle organization and muscle fiber properties affected in myotonic dystrophy.
Whatever the reason, it is nonetheless striking that the modest alternative splicing changes observed in Myo-CELFΔ mice were sufficient to induce changes in muscle organization, fiber size, and fiber subtype.
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But the traditional concept of the muscle system organization still has not changed.
Such hybrid material scaffolds may be useful to direct skeletal muscle cellular organization, improve cellular functionality and tissue formation.
Yuri Gladysh, writing for the opposition Web site kasparov.ru, said the "army of car owners" has enough muscle and organization to alarm Russian officials.
Ultrastructural analysis of the myotomes reveals defects in muscle sarcomeric organization and in myofibers attachment, as well as altered myoseptum integrity.
We then used cell sheets as "functional units" to build complex tissue structures that mimic native vascular smooth muscle cell organization in the medial layer of the artery.
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