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Using RNA-sequencing and pathway analysis tools such as IPA, we were able to define possible primary and secondary factors affecting the breast muscle of affected chickens.
Zn concentrations were higher in the parietal lobe and muscle of affected sheep at 7 months of age, but lower in the liver of 3 month-old and plasma of 7 month-old affected sheep.
In the current study, the differential expression of many genes within the heat shock family and other stress response-related genes suggests the occurrence of oxidative stress within the breast muscle of affected chickens.
The downregulation of this gene within the context of this study may either indicate a deficiency in SELO among birds impacted with Wooden Breast or that seloprotein concentrations are locally diminished within breast muscle of affected birds.
To date, six pathogenic mutations have been described in mt-tRNAGlu (http://www.mitomap.org/), all of which tend to reach either a very high level of heteroplasmy or homoplasmy in the skeletal muscle of affected individuals.
Similar(55)
Through analysis of DE genes in this study, there is ample evidence to suggest that intracellular calcium overload with the potential to impact membrane integrity is occurring in the pectoralis major muscle of broilers affected with Wooden Breast.
Pdgfb was immunolocalized in infiltrating macrophages, regenerating muscle fibres, and myofibre nuclei of affected dystrophic muscle tissue[ 67].
The absence of the sarcoglycan complex in muscle of patients affected by these diseases is reported to expose β-dystroglycan to the activity of a matrix metalloproteinase, thus providing an explanation for its reduced level in sarcoglycanopathies (Ref. 57).
By contrast, the collagen VI α6 chain was normally expressed or increased in the muscle of patients affected by other forms of muscular dystrophy, the overexpression matching with areas of increased fibrosis.
These enzymes can induce haemorrhage, necrosis, oedema, skin damage, and inflammation, and degrade extracellular matrix components and impair the regeneration of affected skeletal muscle [ 6, 9, 15– 17].
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