To investigate the possible contribution of PKG I, we took advantage of a genetic smooth muscle rescue mouse model that lacks expression of PKG I in cardiomyocytes (mouse genotype: PKG IL−/L− SM-Iβ+/−; PKG IL−/L− SM-Iβ+/−[ 49].
Our objective was to demonstrate the activity of SARM molecule (GLPG0492) on a immobilization muscle atrophy mouse model as compared to testosterone propionate (TP) and to identify putative biomarkers in the plasma compartment that might be related to muscle function and potentially translated into the clinical space.
This finding was confirmed by increased Trim62 expression in skeletal muscle of three muscle atrophy mouse models.
Results In this study, the authors show that an injectable collagen matrix is able to successfully regenerate skeletal muscle in a mouse model of muscle necrosis, but not in an atrophic mouse model.
Placental-derived stem cells have the capacity to differentiate into ectodermal, mesodermal, and endodermal cell types, while umbilical cord matrix stem cells, after transplantation, enhanced muscle regeneration in mouse model of severe muscle damage and promoted blood vessel formation and neurological function in animal models of ischaemic brain disease [ 18].
[68] Muscle YAP Mouse models of inducible active YAP in the skeletal muscle cells Loss of body weight, gait impairments and kyphosis.
In addition, FSTL1 is also known to be secreted into the peripheral blood by cardiac and skeletal muscle, especially by ischemic muscle in a mouse model [ 3, 4].
Furthermore, acute inhibition of myostatin/ACVR2B signaling with the antagonist ACVR2B-Fc preserves skeletal muscle in mouse models of cancer cachexia [ 61].
In addition, our results indicate that gene therapy by local Mtm1 transfer in skeletal muscle improves the strength of the targeted muscle in a mouse model of myotubular myopathy and might open novel strategies for treating this disorder.
Previously, activation of Notch was determined to be indispensable for productive regeneration of young muscle, and capable of rescuing the repair of aged muscle in a mouse model of acute tissue injury (Carlson et al, 2008a, 2008b; Conboy et al, 2003; Conboy & Rando, 2002).
