However, the microdialysis data suggest that - provided that there was no increase in muscle blood flow - skeletal muscle was not a major contributor to LPS-induced lactate production.
P104 Microcirculatory effects of norepinephrine in septic shock: a muscle microdialysis study.
Analysis of microcirculation parameters (lactate, pyruvate and lactate/pyruvate ratio) was made every 6 h during the first 3 days by muscle microdialysis (CMA600, CMA microdialysis AB, Stockholm, Sweden).
The aim of our study was to analyze the effects of norepinephrine on metabolic parameters of microcirculation in septic patients studied by muscle microdialysis.
Methods: Twelve anesthetized sheep were subjected to a multimodal hemodynamic/perfusion assessment including hepatic and portal vein catheterizations, total hepatic blood flow, sublingual microcirculation, and muscle microdialysis.
Twelve anesthetized sheep were subjected to a multimodal hemodynamic/perfusion assessment including hepatic and portal vein catheterizations, total hepatic blood flow, sublingual microcirculation, and muscle microdialysis.
Systemic haemodynamics and interstitial tissue concentrations of lactate, pyruvate, glucose and glycerol were obtained at baseline, 6, 12, 18 and 24 h after initiation of renal replacement by using muscle microdialysis.
The aim of our study was to investigate whether CVVH, in comparison to intermittent haemodialysis (IHD), is able to improve regional perfusion in septic shock patients studied by muscle microdialysis.
Eight anesthetized sheep subjected to a multimodal hemodynamic/perfusion assessment including pulmonary artery, hepatic and portal vein catheterizations, portal/hepatic artery flow, gut tonometry, sublingual microcirculation, muscle microdialysis and hepatic mitochondrial high-resolution respirometry, were randomized to LPS or sham.
We aim to allow microdialysis data, either from previous literature or future studies, to be put into perspective alongside results from [18 F]FDOPA and [11C]DTBZ PET.
