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Challenge experiments further demonstrated that the DNA-prime/protein-boost vaccination with Ts87 produced significantly greater muscle larval reduction than the traditional homologous prime-boost vaccination.
The challenge results showed that mice with the DNA-prime/protein-boost vaccination displayed higher muscle larval reduction than those immunized with DNA prime-boost or protein prime-boost.
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In comparison to the PBS control group, mice immunized with DNA prime-protein boost, DNA prime-boost, and protein prime-boost experienced 46.1%, 36.2%, and 24.6% reduction in muscle larval burden, respectively.
This alternative splicing generates isoforms that are differentially expressed in non-muscle, larval muscle and adult muscle tissues [ 24].
Larval muscles undergo reduction: their degenerated parts are visible within the coelom lining (Fig. 14d).
Therefore, environmental management aiming at larval source reduction will contribute little to the overall decrease of malaria burden [96].
Whether or not the adult muscles develop from larval muscle sets is still uncertain, but rather than a complete loss of the complex larval musculature, incorporation of some larval elements into the adult muscular bodyplan by remodeling seems probable.
Alternative approaches that complement larval source reduction should also be considered.
Larval source reduction and control are the most effective methods to deal with the Aedes vector.
Moreover, muscles of larval tentacles are partly retained and integrated into definitive muscles [ 26].
Distinct simplifications of the antennae and labial endite lobes and associated muscles are larval autapomorphies of Holometabola.
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