Muscle lactate efflux value represents the venous-arterial [lactate] difference multiplied by blood flow.
In this study, we have used a quantitative genetic approach to identify imprinted loci that modulate key obesity and muscle traits (body weight, body lean mass, body fat mass, lactate value, muscle glycogen content and muscle glycolytic potential) in mice derived from the Berlin Muscle Mouse Inbred (BMMI) strains.
The finding of a lack of IMP accumulation or ATP decrease during exercise in the present study is consistent with other studies showing that no changes in muscle IMP, ATP or NH3 occur until PCr levels have significantly decreased to values below ∼7 mmol·Kg−1 wet wt [9], [22], muscle lactate reaches 12 18 mmol·Kg−1 wet wt [32] and muscle pH values have fallen below 6.6 [32 ]
Following 1 hr recovery, muscle lactate and phosphocreatine concentrations had returned to resting values, while muscle [ATP] remained 20% lower.
During CVVH muscle lactate decreased constantly, as did muscle glycerol levels.
Lactate values are from ICU admission.
No correlation was found between norepinephrine doses and rate of muscle lactate and muscle lactate/pyruvate ratio (p > 0.05) for all groups: levosimendan, dobutamine and placebo.
This decrease reaches a significant levels at H12 for muscle lactate and at H24 for muscle glycerol (Fig. 13).
Elevated admission lactate values, maximum lactate values during ICU stay, time-to-first-normalization, and lactate-time-integral were all associated with in-hospital mortality.
Definitions for the following abbreviations are provided for mH+ (muscle protons), mLa− (muscle lactate), MCT (monocarboxylate transporters), bLa− (blood lactate) and [PCr]/[Pi] (ratio of phosphocreatine to inorganic phosphate).
