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Muscle is sensitive to sex steroids, and thus peristalsis is greatest when oestrogen levels are high [20].
ESR1 was recently shown to be expressed in human skeletal muscle [36] implying that skeletal muscle is sensitive to estrogen signaling, albeit to date the overall effects of estrogen on skeletal muscle remain poorly understood.
Although IGF1 gene expression in muscle is sensitive to testosterone depletion or administration in men [18], [29], no sex difference in plasma IGF-1 levels or muscle IGF1 gene expression has been observed [10].
38 Owing to its high-energy demand, the skeletal muscle is sensitive to changes in partial pressure of O2.
Muscle is sensitive to the protocols of contraction and work to which it is submitted, since its structure is designed to support these protocols and to adapt to new situations of force.
We report here that expression of SIRT3 in skeletal muscle is sensitive to various signals from both diet and exercise, leading to downstream activation of AMPK and up-regulation of PGC-1α.
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Additionally, we find that SIRT3 protein levels in skeletal muscle are sensitive to diet, for SIRT3 expression increases by fasting and caloric restriction, yet it is decreased by high-fat diet.
The pain receptors in the muscles are sensitive both to shortening of the fibers and to a buildup of metabolites.
These findings suggest that the ability of muscle fibres to maintain more than one nerve terminal, like other muscle properties, is sensitive to the pattern of muscle use rather than just the total amount of use.
Muscle contractility is sensitive to reduction-oxidation (redox) balance, such that elevated levels of oxidants can suppress muscle-specific force (see ref. 33 for review), and there is now compelling evidence that oxidative stress plays a major role in VIDD (10, 13, 14, 15).
Muscle, likewise, is sensitive to the damaging effect of shrapnel, being readily torn and unable to survive diminished blood supply for any appreciable time.
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