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This may contribute to the age-related increase in muscle damage as a stiffer muscle is less compliant and less capable of absorbing mechanical strains during eccentric contractions.

The septal papillary muscle is less prominent, even absent in 20% of cases and often rudimentary, providing chordae to the septal and posterior leaflets.

Possible options might be transplantation in juvenile mice (where the muscle is less "primed" by inflammation) [ 92], neonatal desensitization [ 116], or evasion of macrophage killing [ 117, 118].

4 Several studies have shown how aged muscle is less responsive to the anabolic stimuli of amino acids and exercise, 5, 6 a concept now commonly referred to as anabolic resistance.

In terms of plasmid delivery in primates, direct injection into muscle is less efficient than in rodents [ 42] and may indicate that alternative delivery methods will be required for treatment of patients.

However, as observed with motor unit survival and NMJ innervation, no deficit in EDL muscle force was detected in Sod1 D83G/D83G mice at 15 weeks, confirming that this muscle is less vulnerable to the effects of mutant SOD1 than other hindlimb fast twitch muscles.

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In group 1 mean CV for each muscle was less than 6% and Bland Altman analysis showed excellent agreement between examinations.

Thus, it is possible that there is also a lower expression of peripheral NMDA receptors by nociceptors that innervate the temporalis muscle in healthy human subjects, which results in the temporalis muscle being less sensitive to orally consumed MSG than the masseter muscle [24].

These investigators generated transgenic mice expressing a mutant PKGIα that was unable to interact with MYPT1, and compared to WT controls, the transgenic mice were both hypertensive and the vascular smooth muscle was less sensitive to both ACh and cGMP mediated vasodilatation.

Moreover, during chewing the masseter muscle was less active in patients with crossbite than in the subjects in the control group.

Using the muscle serratus anterior as a reference, there was no significant interobserver variability (P = 0.065, Table 3), while the subscapularis muscle was less reproducible between two readers (P = 0.039, Table 3).

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