Potential target genes of rno-miR-21 that were identified from downregulated mRNA in the experimental muscles in the whole genome expression array experiments after reperfusion for 1, 3, 7, and 14 d following 4 h of ischemia as well as from either the miRanda or RNAhybrid prediction algorithm.
We performed bioinformatics analysis of whole genome expression profiling of muscle specimens and UPLC/MS based lipidomics analyses of plasma samples obtained in an earlier randomized trial from patients either on high dose simvastatin (80 mg), atorvastatin (40 mg), or placebo.
As part of this action, the two studies found that genes relevant to the changes seen in liver (Baur et al 2006) and skeletal muscle (Lagouge et al 2006) were induced, as identified by whole genome expression profiling.
We used the muscle specimens that underwent ischemic injury at 1, 3, 7, and 14 d after reperfusion for the whole genome expression experiments.
We utilized a whole genome expression microarray and an F2 pig resource population to conduct a global eQTL analysis in loin muscle tissue, and compared results to previously inferred phenotypic QTL (pQTL) from the same experimental cross.
These observations, of developmental and brain/muscle specific patterns, are in accordance with the similar type of observations made for the mitochondrial genome expression presented above.
extracted from whole genome expression.
In their second study [ 16 ▪], the group investigated the epigenetic regulation of muscle gene expression by carrying out whole-genome DNA methylation profiling on muscle tissue from JDM patients prior to treatment.
genome expressions, physiological states, environmental conditions, etc.
In this study, Chicken Genome Arrays (20 K) were used to compare muscle gene expression profiles of chickens from Fat (F) and Lean (L) lines that exhibited high and low muscle glycogen content, respectively, and of individuals exhibiting extremely high (G+) or low (G-) muscle glycogen content originating from the F2 cross between the Fat and Lean lines.
