Sentence examples for muscle fusion process from inspiring English sources

However, investigation of the visceral muscle fusion process in ΔC3GMS mutant animals indicates that C3G activity is not essential for this process (Figure S2 C and D).

Considering that a significant body of evidence has emerged describing similarities in cellular processes between fly and man [ 35] it is tempting to hypothesise that interaction of Kirrel3 and nephrin in human skeletal muscle may facilitate the muscle cell fusion process.

In Drosophila redundancy is present between Kirre and Rst with regard to the muscle cell fusion process [ 19] and redundancy may also be present among the Kirrel family members for the muscle cell fusion process in humans.

Such redundancy should be considered when attempting to ascertain the possible roles of the Kirrel family members in the human muscle cell fusion process.

While its presence alone would not confirm a role in the human muscle cell fusion process, it would provide initial support for further investigation.

Nephrin is the mammalian homolog to the Drosophila gene, sticks and stones, that is essential for the muscle cell fusion process during embryonic fly development [ 20].

Research findings from Drosophila have highlighted that key events in the muscle cell fusion process are cell-cell attraction, adhesion and subsequent actin nucleation at sites of cell-cell adhesion, the latter enabling membrane fusion [ 15– 17].

Our rationale for investigating Kirrel3 in human skeletal muscle was derived from research studies in Drosophila that demonstrated the involvement of two genes, Kirre and Rst, in the muscle cell fusion process during embryonic development [ 19].

A wide variety of genes impact on the muscle cell fusion process ranging from actin nucleation factors, such as those found in the actin related protein 2/3 complex [ 18], to type 1 transmembrane receptors [ 19, 20].

These observations suggested that, in P1b-KO muscle, mitochondrial fusion processes were increased, similar to MCK-Cre/cKO muscle.

While our research findings do not prove a role for Kirrel3 in the cell fusion process in adult human muscle, they do raise interesting questions regarding the function of Kirrel3 in human myogenesis and even in uninjured human skeletal muscle fibres.