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All of the subjects underwent one familiarization session prior to the muscle function tests.
Muscle function tests were performed 15w following surgery using the auto-perfused hind limb.
During these visits, blood tests, anthropometry, body composition, bone assessments, and muscle function tests are performed.
These studies were centered on the actions of Se on muscle function tests and included dynamometric analysis.
The coefficients of variation (CV) for the muscle function tests were 3.0%, 4.1%, 2.6%, and 1.7% for the 1RM leg press, 1RM knee extension, TST, and TUG, respectively.
The concentrations used in the animal experiments were determined by a preliminary study where a spectrum of S&H doses was screened by muscle function tests in a small group of Dmdmdx mice.
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Changes in physical endurance was reported based on physical examinations and tests such as Sorensen Test and Active Straight Leg Raising ASLRR) test [ 47] and muscle function test [ 48].
The improvement in the foot-flattening phase after the intervention is also supported by the decreased ankle extensor moment, the improvement in the ankle dorsiflexion (functional tests) and in the function of the tibialis anterior (manual muscle function test).
The investigators tracked the molecular phenomenology after VML over 56 days using muscle function testing, histology, and gene expression profiling using high-throughput sequencing (RNA-sequencing).
Main Outcome Measures: Gait function (speed, endurance, walking status, use of assistive device and orthotics); oxygen costs of walking; brain motor control assessment; self-report indices; ASIA classification; muscle function test; and safety.
dmedian and interquartile interval; muscle function test gradation (Kendall et al., 2005): 5:holds test position against maximal resistance.
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