In general, therapy is expected to include exercises to improve mobility and muscle function, passive mobilizations, instructions (posture and movement), massages and ice packages [ 8].
The relationship between strength and mobility tasks is curvilinear, suggesting that other factors than muscle function contribute to mobility, still muscle strength is considered the most important factor to enhance mobility [ 21, 22].
To provide reference values of muscle function (MF) and mobility performance (MP) and to clarify the effects of MF on MP.
Modifications of the morphophysiological muscle tissue favor decreases in mass, strength and muscle function, which impacts mobility, increases the risk of falls and contributes to fragility [ 9].
Based on these studies and because we observed that patients with the most affected muscle function (wheelchair-limited mobility) have the lowest concentration of IL-1, TNF- α, and CK compared with patients with less muscle damage (independent ambulation), we hypothesized that the decrease in concentration of these cytokines and CK may result from muscle loss in DMD patients.
The CAP includes variables on joint mobility, muscle function, morphology and functional activity (Table 1).
The American Society for Nutrition and the Obesity Society have highlighted the need for long-term randomized clinical trials to evaluate the independent and additive effects of diet-induced weight loss (WL) and physical activity in older persons on outcomes such as mobility, muscle function, and obesity related diseases.
(rs = 0.06), the CAP muscle function nor the CAP mobility II (rs = 0.2 respectively 0.09).
The finding that muscle force is clearly improved by the combination treatment in the dy W / dy W mice further suggest that such a therapy might be particularly beneficial to improve muscle function and thus the mobility of MDC1A patients.
