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Unfortunately, since pre-hospital functional status of these patients is almost always unknown, it is difficult to know how baseline muscle function contributes to long-term functional outcomes.
Impaired skeletal muscle function contributes to exercise intolerance in patients with COPD.
Skeletal muscle is a major contributor to resting levels of energy expenditure [ 1], and reduced skeletal muscle function contributes to age-induced obesity and diabetes.
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The relationship between strength and mobility tasks is curvilinear, suggesting that other factors than muscle function contribute to mobility, still muscle strength is considered the most important factor to enhance mobility [ 21, 22].
Hyperactivity of the masticatory muscle function can contribute to the increases in mandibular bone growth, size, and structure [22].
Even less is known about how changes in muscle function might contribute to the worsening of knee OA.
Similarly, little is known about how sex-related changes in muscle function might contribute to the worsening of knee OA.
8, 9 Consistent with the importance of mitochondria in healthy muscle, impairments in skeletal muscle function that contribute to obesity-related disease (eg, decreased fatty acid oxidation, impaired insulin sensitivity) are causally linked to decreases in mitochondrial content and function.
Combined with the loss in muscle mass, progressive changes in muscle function will contribute to an increased sense of frailty in elderly men and women with impairments in balance, gait speed, and an increased risk of falls (Madureira et al. 2010).
Disruption of skeletal muscle function may also contribute to insulin resistance and diabetes caused by overnutrition and obesity [ 2].
This combination of effects is certainly detrimental to skeletal muscle function and will contribute to the decline in muscle strength with aging.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com