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Duchenne muscular dystrophy (DMD) is an inherited X-linked disease caused by mutations in the gene encoding dystrophin, a protein required for muscle fiber integrity.
These defects are not due to defects in muscle fiber integrity or number (Fig. S8 and [16]).
Plectin, a versatile 500-kDa cytolinker protein, is essential for muscle fiber integrity and function.
These changes would lead to improvements in muscle fiber integrity in dystrophin-deficient muscle to slow the disease process.
In comparison with the results obtained from the trial animals, loss of muscle fiber integrity seems to play only a role during acute and subacute besnoitiosis.
Disruption of one (P1d) or both (P1f and P1d) of these IF-linking elements inevitably leads to the loss of muscle fiber integrity.
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This model may ensure a coordinated delay in re-attachment of motoneuron terminals onto damaged fibers early in muscle regeneration, and thus synchronize the recovery of muscle-fiber integrity and the early resolution of inflammation after injury.
Normal cardiac muscle fibers with cellular integrity were observed in normal untreated rats).
Basal autophagy is highly essential for muscle fiber homeostasis and maintenance of their integrity, while autophagy inhibition enhances muscle loss (Masiero et al., 2009).
Fiber integrity was also tested in the Drosophila muscle by staining larval body wall muscle from transgenic flies expressing wild-type and mutant Lamin C with Evans Blue dye, which only penetrates cells in which the membrane is disrupted.
Based on our findings, HGF/Met might be a new target for reducing inflammation, prolonging fiber integrity and delaying disease progression in dystrophic muscle.
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muscle fiber action
muscle fiber component
muscle fiber typing
muscle fiber hypertrophy
muscle fiber morphology
muscle fiber area
muscle fiber cellularization
muscle fiber generation
muscle fiber formation
muscle fiber diameter
muscle fiber plasticity
muscle fiber nucleus
muscle fiber wasting
muscle fiber growth
muscle membrane integrity
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