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Several pathways related to muscle development were enriched with predicted targets for the differentially expressed miRNAs.
Cardiac myoblasts isolated from canine embryonic hearts characterized by expression of myocardin A, a promyogenic transcription factor for cardiovascular muscle development were pretreated with Epo and then exposed to TNF-α.
Thus, our results indicated that the regulation of muscle development were more complex than previously acknowledged.
The gene set enrichment analysis, which involved all of the genes on the array, demonstrated that genes involved with muscle development were among the significant GO identifiers.
However, although fewer modules of myogenesis and muscle growth were identified in LT, more modules related to slow muscle fiber and negative regulation of muscle development were found.
Although muscle phenotype was found to be determined during embryonic development, several hub genes related to muscle development were identified in these modules.
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Myoglobin, which is needed for muscle development, is also protein.
Greater leg muscle development was found in males of the Parc Cwm cromlech, possibly the result of hunting or herding, confirming the sexual dimorphism found in previous analyses of the remains.
Also, some principles of muscle development are similar [3], [4].
Mid-arm muscle development is enhanced with greater levels of physical activity.
Understanding muscle development is crucial for generating novel regenerative therapies for muscle diseases and treating muscle injuries.
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