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We identified the STAND domain in several biologically well-characterized proteins that have not been suspected to have NTPase activity, including soluble adenylyl cyclases, nephrocystin 3 (implicated in polycystic kidney disease), and Rolling pebble (a regulator of muscle development); these findings are expected to facilitate elucidation of the functions of these proteins.
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Several miRNAs are highly regulated in vivo and in vitro during muscle development and these regulate the muscle differential expression process [ 55].
To identify the miRNAs that might be involved in muscle development and to discriminate these from the miRNAs possibly involved in promoting or repressing muscle myogenesis and differentiation, we carried out a comparative miRNA expression profile across skeletal muscle samples collected from pigs of 33-days post-gestation (E33), 65-days post-gestation (E65) and adult age (Adu).
Although muscle phenotype was found to be determined during embryonic development, several hub genes related to muscle development were identified in these modules.
In the future, it may be interesting to study the functional role of Huwe1 and UPS10 during muscle development in vivo and how these two enzymes may regulate TBP protein levels in mouse models.
These treatments, which help muscle development, can be critical for babies with Zika-associated birth defects.
These genes belong to muscle development, cell cycle arrest, metallothioneins and autophagy-lysosome system.
We observed that neither muscle development nor animal longevity was compromised in these transgenic animals.
Most of these proteins are essential for muscle development and were identified through genetic screens for mutants exhibiting arrested, or abnormal muscle development (reviewed by [8] [10]).
Collectively, there is strong evidence for the involvement of these transcription factors in regulating muscle development.
These myogenic miRNAs (myomiRs) regulate muscle development by fine-tuning gene expression or acting as binary on/off switches.
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