Also, some principles of muscle development are similar [3], [4].
Down the corridor, her colleague Professor Simon Hughes is doing something similar on skeletal muscle development.
Indeed, similar varying levels of slow muscle development defects have been described in the different Hh pathway genetic mutants [46], potentially indicating compensatory effects by other genes in the Hedgehog pathway.
In comparison to the high abundance of miR-206 in muscle tissue, porcine miR-1 had relatively moderate abundance that increased throughout development, similar to the pattern observed for this miR in mouse muscle development [ 16].
Our approach not only recapitulated the basics of muscle development and physiology, as the obtained myotubes showed qualities similar to those seen in striated muscle fibers in vivo, but also allowed for the synthesis of populations of myotubes which assumed distinct morphology, myofibrillar development and Ca2+ dynamics.
A genome scan in chicken revealed a similar pattern – several genes related to growth, muscle development and skin color (yellow skin) were identified as having been under positive selection [38].
These results suggested that the conserved coexpression network modules contained genes that were associated with the regulation of basic muscle development; implying that the key processes that regulate muscle development are similar in the two breeds.
In a similar approach, using promoters representing various stages of muscle development (cdh15, rag2, mylz2), Storer et al. [ 34] drove expression of KRASG12D and observed that tumors that originated from the more progenitor like cells were more invasive and undifferentiated.
Interestingly, Smn protein expression from P2 to P21 follows a very similar trend suggesting a need for Smn early in muscle development (Supplementary Material, Fig. S1A).
Two other mutants isolated from the same screen, apx-1 wy750) apx-1 wy750wy760), were very similandto the lin-12(wy750) mutant in their sel-12 wy760ective sel-12 wy760rm development and normal vulval muscle development.
Col25a1 expression is required for muscle development in mice.
