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However, late steps of tendon and muscle development require reciprocal interactions.
First, vm2 muscle arm development requires a high level of LIN-12/Notch signaling activity, while vulval morphogenesis and overall muscle development require low activity of LIN-12.
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10.7554/eLife.00378.018 Figure 5. vm2 muscle arm development requires APX-1-induced LIN-12/Notch signaling activity.
DOI: http://dx.doi.org/10.7554/eLife.00378.018 10.7554/eLiFigure78.019 Figure 5 figure supplement 1. vm2 muscle arm development requires high LIN-12/Notch signaling activity.
Notably, the transcription factor myogenin, an essential regulator of muscle development, is required for the maximal activation of these two genes, at least during denervation (Moresi et al., 2010).
Speech and language development requires stimulation.
The development requires several years of research.
Economic development requires investment.
Successful community development requires community participation.
At least some of these 96 kinases are likely to be required for normal protein synthesis during development, for example EGL-15 which is required for proper muscle development [ 19], but further experiments are required to confirm to what extent genes identified in the chronic screen may regulate synthesis, degradation, or both.
Responses to these developments require effective leadership.
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