Thereby telethonin plays an important role in myofibril assembly and in muscle development and functional regulation.
A comparison of these clusters with regions stably weakly expressed during commitment phase of myelopoiesis, identified with LAP, showed overlap with clusters related to functional modules of muscle development or function, nervous system development, skeletal development and visual perception (Additional file 5).
Genes pertaining to 8 functional modules related to development or function of non-hematopoietic organs were identified: embryonic development, epidermis development, eye development, muscle development and function, nervous system development, skeletal development, spermatogenesis, visual perception.
Functional analysis showed that muscle development related GO terms were enriched among differentially expressed genes.
Indeed, FST is a key functional gene that regulates muscle development, and its regulatory mechanisms in muscle development were recently studied more intensively by many researchers in the field.
Breed-specific modules that regulated muscle phenotype divergence were identified, and hundreds of hub genes with major roles in muscle development were determined to be responsible for key functional distinctions between breeds.
Therefore, we decided to investigate the functional role of cited3 in skeletal muscle development.
At puberty, the phenotype of these individuals changes to a more normal male pattern manifested by development of a functional penis, deepening of the voice, muscle development, etc.
To investigate the functional roles of miRNAs during chicken skeletal muscle development, an interaction network of the differentially expressed miRNAs and their putative targets was constructed.
Although the functional roles of Cited genes in skeletal muscle development have not been studied, they are important for mammalian development and have been implicated in cardiac (Sperling et al., 2005; Boström et al., 2010; MacDonald et al., 2012) and skeletal muscle (Pescatori et al., 2007; Sáenz et al., 2008; Tobimatsu et al., 2009) defects.
