These markers may have utility in detecting arrest or reversal of muscle denervation prior to changes in motor function, which would be advantageous when assessing efficacy of experimental therapies.
To investigate whether Pax7 and MyoD levels could change following muscle denervation, we experimentally denervated wild-type mice.
However, electromyogram (EMG) revealed chronic denervation changes in the right deltoid and right trapezius muscle, consistent with right brachial plexopathy.
A long period of muscle denervation has many adverse effects such as muscle fiber atrophy, neuromuscular junction changes, increased fibrosis in the distal nerve, and a decline in Schwann cells in the distal nerve [ 16].
To determine the relationship among spinal stenosis, back pain, paraspinal muscle denervation, and paraspinal muscle atrophy.
In the mSOD1G93A mouse model, a decrease in hindlimb muscle fiber size is noticeable between postnatal weeks eight & nine29, which follows closely after initial significant muscle denervation in this muscle group5,6.
Using new needle electromyographic technique, MiniPM, we may be able to quantify the extent of paraspinal muscle denervation.
Detection of MR signs of muscle denervation should be regarded as indicative of surgical nerve decompression.
MR signs of muscle denervation within the anterior compartment are important secondary signs for evaluation of the peroneal nerve.
In cases of primary muscle involvement, initial ossification starts in the peripheral tissue due to oedema and capillary stasis following muscle denervation [3].
