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Age-related muscle decline and the potential benefit from the use of HRT were also evident in the current study, but despite the age-related differences in systemic hormone concentrations, the intramuscular E2, T, and DHEA concentrations were similar in both pre- and postmenopausal women regardless of their HRT status.
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However, as the disease progresses, the regenerative potential of dystrophic muscles declines and myofibre repair becomes biased toward the formation of fibrotic scars and fat infiltration (Serrano et al, 2011).
The finding that levels of immunoreactive AVP, which are high in embryonic skeletal muscle, decline during gestation and reach very low levels at birth points to a role of AVP in muscle development [ 65].
Therefore, our results propose a mechanism whereby further NMJ and skeletal muscle decline ensues upon SC depletion and neuromuscular disruption.
Sarcopenia, the age-related skeletal muscle decline, is associated with relevant clinical and socioeconomic negative outcomes in older persons.
IL6 blockade counters muscle decline in mdx mice.
The diameter of the fibers from the soleus muscle declined with age and unweighting.
The regenerative potential of skeletal muscle declines with age, and this impairment is associated with an increase in tissue fibrosis.
The regenerative potential of skeletal muscle declines with age and this impairment is associated with an increase in tissue fibrosis [5].
We propose that an active lifestyle is an important determinant of quality of life and molecular progression of aging in skeletal muscle of the elderly, and is a viable therapy for attenuating and/or reversing skeletal muscle strength declines and mitochondrial abnormalities associated with aging.
Muscle strength declines and accelerates further with age [ 1, 2].
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