Sentence examples for muscle ceramide level from inspiring English sources

We aimed to measure IS, muscle ceramide level, protein synthesis, and activation of intracellular signaling pathways involved in translation initiation in male Wistar young (YR, 6-month) and old (OR, 25-month) rats receiving a low- (LFD) or a high-fat diet (HFD) for 10 weeks.

Ceramide content was measured in TA muscle overexpressing DGAT1 and in the contralateral empty vector electroporated legs to determine whether the increase in IMCL content is linked to changes in muscle ceramide levels (figure 3).

In our study, IR was induced by HFD feeding in the absence of any elevation in whole-muscle ceramide levels.

Previous reports have revealed that the level of muscle ceramide enriched with nervonic acid is negatively correlated with insulin sensitivity, but the authors did not examine plasma lipid levels.

Consequently, OR fed the HFD were insulin resistant, showed a strong increase in intramuscular ceramide level and a decrease in muscle protein synthesis associated with increased eIF2α phosphorylation.

Further research has been performed by Skovbro et al. showing that human skeletal muscle ceramide content is not a major factor in muscle insulin sensitivity (Skovbro et al. 2008).

By using euglycemic-hyperinsulinemic clamps with muscle biopsies, it has been observed that muscle ceramide content is significantly correlated with the plasma FFA concentration in lean insulin-sensitive and obese insulin-resistant subjects (Adams et al. 2004).

Interestingly, ceramide level does not change upon differentiation (Figure S3).

In addition, our data show that DNL contributed relatively less stearoyl- than sphingosine-moiety to muscle c18 ceramide, suggesting that low SCD1 activity in muscle could be responsible for the increased dependency of muscle ceramide accumulation on dietary fat.

DNL-derived fatty acids were found to contribute more to ceramide synthesis in liver than in muscle, but a significant time-dependent increase in muscle ceramide was observed between 2 and 8 weeks of HFD feeding.

Moreover, it seems that in cancer cells increased ceramide glycosylation to glucosylceramide leads to decreasing ceramide level.