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Advantages include large muscle cell size, a stereotyped arrangement of mitochondria that is conserved in mammalian muscles, and the ability to analyze muscle-specific gene function in mutants that are lethal prior to adult stages.
The targeting of eIF3f in the atrophic pathway regulated by MAFbx in muscle atrophy suggested an unexpected implication for eIF3f in the control of muscle cell size.
This means that HDACs control muscle cell size on multiple levels.
An influence of PLD on muscle cell size could thus be suspected.
We further demonstrated that the changes in muscle cell size induced by PLD were mediated by mTOR.
However, despite these evidences a direct demonstration of PLD implication in the regulation of muscle cell size remains to be provided.
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Many researchers have made great efforts to investigate the divergent muscle growth rates and muscle cell sizes of broilers and layers and attempted to decipher the underlining mechanisms of above phenomena.
For example, resistance training effectively remodels myofibrils, fiber type compositions, mitochondrial content, and muscle cell sizes (Seynnes et al, 2007), leading to body and skeletal muscle mass increases of 2 5 kg and strength gains of 5 20% within one week in athletes after optimal exercise and nutrition (for review, see Hartgens and Kuipers, 2004).
At 24 hours postmortem, carcass data were collected and samples obtained from subcutaneous and intramuscular adipose tissues of the longissimus muscle for cell size determination.
In salmonid species both hyperplasia (muscle growth by cell division) as well as hypertrophy (muscle growth by cell size) occur continuously during adulthood, in contrast to mammals that show only hypertrophy occurring during adulthood (reviewed by [9]).
Figure 1 (b) clearly shows a muscle cell nucleus given its size (~6.5μm × 21μm), elongated oval shape and subsarcolemmal localization.
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