The scientists conducted several experiments to figure out how the TBX20 abnormality changes heart muscle cell proliferation -- with the abnormality, the cells don't proliferate enough, it turns out.
Chatterjee, S. & Ghosh, N. Oxidized low density lipoprotein stimulates aortic smooth muscle cell proliferation.
Oh, H. et al. Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival.
A hypothesis is that mechanical stimulus triggers human bladder smooth muscle cell proliferation.
In addition to reducing cholesterol levels, statins may modulate smooth muscle cell proliferation and migration.
Li F, Li L, Qin X, Pan W, Feng F, Chen F, et al. Apelin-induced vascular smooth muscle cell proliferation: the regulation of cyclin D1.
Zou, J. J., Gao, Y. D., Geng, S. & Yang, J. Role of STIM1/Orai1-mediated store-operated Ca(2) entry in airway smooth muscle cell proliferation.
Villa, A. et al. Effects of antisense c-myb oligonucleotides on vascular smooth muscle cell proliferation and response to vessel wall injury.
Thus, inhibition of fetal pulmonary artery smooth muscle cell proliferation by heparin is not mediated solely by decreased availability or activity of exogenous PDGF.
In conclusion, thrombin inhibition by Hirulog administration does not reduce acutely (within 3 days) vascular smooth muscle cell proliferation or inflammatory activation after angioplasty.
Together, these results suggest that acute thrombin generation is not a crucial stimulus for early smooth muscle cell proliferation and inflammatory activation after vascular injury.
