Sentence examples for muscle cell dysfunction from inspiring English sources

Our findings strongly suggest that, in I-MetS, the augmented vasoconstriction was caused by vascular smooth muscle cell dysfunction.

In 8 of the 16 patients, multiple ischaemic-like lesions occurred in the cerebellar cortex suggestive of vascular smooth muscle cell dysfunction.

It cannot be ruled out that pericytes, astrocytes, or vascular smooth muscle cell dysfunction due to telomere shortening affects BBB integrity in this mouse model.

The precise mechanisms of mineralization are not well understood; however, it has been postulated that vascular smooth muscle cell dysfunction is the main driving force for mineralization (Speer et al., 2009).

These findings suggest that the onset of hypertension in MetS is strongly influenced by vascular smooth muscle cell dysfunction and independent of important factors known to influence microvascular function and consequently blood pressure levels.

Vascular endothelial and smooth muscle cell dysfunction as well as large arterial stiffness are considered to be markers of subclinical atherosclerosis with a significant prognostic role in high risk populations [ 3- 10].

She has developed a high-throughput phenotypic screen to identify compounds that reverse PAH endothelial cell (EC) and smooth muscle cell (SMC) dysfunction in a patient-specific manner.

We propose that telomere shortening rather than accumulated DNA damage is responsible for age-associated muscle stem cell dysfunction and consequent loss of regenerative capacity.

These data indicate that GDF11 systemically regulates muscle aging and may be therapeutically useful for reversing age-related skeletal muscle and stem cell dysfunction.

Other arsenic toxicity mechanisms that have been suggested include vascular smooth muscle cell proliferation and dysfunction (Bae et al. 2008), inhibited endothelial nitric oxide synthase activity (Kao et al. 2003; Lee et al. 2003), smooth muscle cell migration (Simeonova and Luster 2004), and enhanced platelet aggregation (Lee et al. 2002).

Lavasani, M. et al. Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model.