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PPT were lower at points over the extensor carpi radialis brevis (ECRB) muscle as compared to points over the extensor digitorum communis muscle (P <.01) and over the extensor carpi ulnaris muscle (P <.001).
The muscle specific differences observed in the expression of developmental MHC with age may be influenced by the fiber type and function differences of this muscle as compared with the soleus.
These counterintuitive findings may be due, at least in part, to the ability of mECM to attenuate muscle damage in the remaining muscle as compared to non-repaired muscle.
Interestingly, gene expression levels mediated by PPE-MEA and PPE-HA in mouse muscle following intramuscular injection of complexes showed a reversed order: PPE-MEA/DNA complexes mediated a 1.5 2-fold higher luciferase expression in mouse muscle as compared with naked DNA injection, while PPE-HA/DNA complexes induced delayed and lowered luciferase expression than naked DNA.
There was a higher activity in both bacterial infected and sterile inflamed thigh muscle as compared to healthy thigh muscle.
This is consistent with the greater muscle loss we report in RF (extensor muscle) as compared to AT (flexor muscle).
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Despite low FPKM values, OR10AB1P was selectively expressed in striated muscles as compared to other tissues, with strongest immunoreactivity observed in skeletal muscle.
Data from IP assays showed an increased association between SIRT-1 and PARP-1 proteins in exercised muscles as compared to intra-animal non-exercised muscles (Fig. 1H).
Firstly, the mRNA expression of these 4 genes was markedly lower in skeletal muscles as compared to LV myocardium (in both healthy and diseased animals).
In the absence of acute damage, tamoxifen-treated mice did not present significant alterations or lesions in skeletal muscles, as compared with vehicle-treated controls (Supplementary Figure 14c).
Analysis of glycogen levels by Periodic acid Schiff (PAS) staining revealed a sharp increase in glycogen accumulation in Vps15-deficient muscles as compared to control and Atg7-deficient muscles (Fig. 8A).
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