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(C ) Quantification of muscle arm phenotype in animals with different genotypes indicated on the X-axis.
The percentages of animals with normal or defective muscle arm phenotype are indicated by dark or light gray bars, respectively.
(B ) Schematic illustration of the molecular lesion (top) and muscle arm phenotype (bottom) of lin-12 e2621). lin-12 e2621
The major concern of all three reviewers centers on the interpretation of the muscle arm phenotype as a defect in synapse specificity.
Hence, the muscle arm phenotype shown in lin-12 wy750) lin-12 wy750t likely the consequence of a comutant cell-fate conversisnot
This recombineered fosmid fully rescued the lin-12 muscle arm phenotype, suggesting that this construct should contain all upstream, downstream and intronic regulatory elements crucial for proper expression and function of lin-12.
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Note that unc-40 e271) unc-40 e271ok2226) show missing (middle) or andormadd-2 ok2226uscle madd-2 ok2226show
(B ) Quantification of muscle arm phenotypes in animals with different genotypes indicated on the X-axis.
Quantification of muscle arm phenotypes in animals with different genotypes indicated on the X-axis.
(C ) Quantification of the vm2 muscle arm phenotypes in the mosaic transgenic animals.
Since both unc-40 and madd-2 mutants showed muscle arm phenotypes, we investigated whether they functioned in the same or parallel pathways.
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