All the UBL domain-containing genes in the genomes of Homo sapiens and Mus musculus were obtained from the Celera database (database currently not available).
Reference genome sequence data from Mus musculus were obtained from the University of California Santa Cruz Genome Browser Gateway (assembly ID: mm10).
Male Swiss mice (Mus musculus) were obtained from the Central Biotherium of the State University of Maringá.
MSM/Ms mice and Mus spretus were obtained from the Riken BioResource Center (Tsukuba, Ibaraki, Japan).
Bit scores for homologs of all the proteins of Mus musculus were obtained by protein BLAST search [ 30] against proteomes of 213 species.
The unnanotated genomic sequences of the keratin gene clusters from dolphin (Tursiops truncatus), cow (Bos taurus), dog (Canis familiaris), horse (Equus caballus), little brown bat (Myotis lucifugus) and mouse (Mus musculus) were obtained in Ensembl database.
Pseudogene sequences in humans (Homo sapiens), five other primates (Pan troglodytes, Gorilla gorilla, Pongo abelii, Nomascus leucogenys and Microcebus murinus) and one rodent (Mus musculus), were obtained from the Ensembl Genome Browser [ 31, 32].
After considering the body surface area index [ 23], doses were selected which were also corresponding to the human exposure of isoflavonoids [ 8]. 25 30 gm, 10 12-week-old 10 12-week-old 10 12-week-oldusculus) were obtained fromaleboratory Animal DiviSwiss Centralbinog Research Institute, Lucknow.
Csnk2b and Ly6g5b orthologue ORF sequences Homo sapiens, Macaca mulata, Sus scrofa, Bos taurus, Rattus norvegicus and Mus musculus were obtained from the National Centre for Biotechnology Information (NCBI) (http://www.ncbi.nlm.nih.gov/BLAST/) [ 42].
Gene sets for the mus musculus genome were obtained from the Walter and Eliza Hall Institute (WEHI, Parkville VIC, Australia).
