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Compared to the human ATF6 3′UTR which is 408 bp, the murine version is significantly longer at 5,422 bp.
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Despite 91 % amino acid sequence similarity between Chinese Hamster TRP-2 and murine TRP-2, the signal peptidase cleavage sequence varies considerably and the murine version was unable to promote proper localization in the CHO-S system (data not shown).
Among 15 human formins, Drf3 (murine version, mDia2) is established best to induce filopodia [ 6 8], but its role in lamellipodia formation is ambiguous because its RNAi-mediated knockdown both inhibited [ 8] and promoted [ 9] lamellipodia.
The theatrical version is my final version".
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ACE-536, or its murine version RAP-536, has been shown to be active in mouse models of conditions in which endogenous EPO levels are elevated and exogenous ESAs are either ineffective, such as in β-thalassemia, or face resistance or refractoriness, such as in MDS.
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CEO of Professional Science Editing for Scientists @ prosciediting.com