To test the hypothesis that BCG in vivo can induce a switch to systemic aerobic glycolysis with clinical significance, i.e., sufficient to lower blood sugars, we turned to murine testing.
Lund, L. H. et al. Signal sequence deletion and fusion to tetanus toxoid epitope augment antitumor immune responses to a human carcinoembryonic antigen (CEA) plasmid DNA vaccine in a murine test system.
Good results were recorded on murine skin tests in case of polyurethane microstructures based on isophorone diisocyanate.
We observed that mRNAs encoding Tmc5, Tmc6, Tmc4 and Tmc7 are expressed in most murine organs tested.
This suggests that SBP has a therapeutic window of between 0.19 µM and 1.63 µM for the murine cells tested.
The current paradigm of murine researchers testing compounds with a focus on prepulse inhibition and the water maze is outdated, not translatable to the clinic in any way, and only serves to stagnate the field.
Murine typhus diagnostic tests were performed by the WHO Collaborating Centre for Rickettsial Diseases (Marseille, France) (7 ).
Although excellent for studying pathomechanisms and for very targeted therapy development and testing, murine models are not amenable to larger scale testing of potential chemical modifiers of disease.
Furthermore, for the complete set of 21 clinical isolates tested in this study, there was a significant correlation between the murine MSTs and test-statistics (Spearman's rho, r s=−0.709 and P<0.01).
Of these, 97 had not previously been tested in murine models; 22 had been tested in murine models, but their interactions with host proteins are not known.
