To examine whether this miR206 LXRα regulatory pathway is also operative in murine systems, we studied MPMs and BMDMs obtained from miR-206 KO and WT mice.
In agreement with these data from the murine system, when we tested IGF2 mRNA levels in the osteoporotic bone samples, in which miR-483-5p miR-483-5p miR-483-5pobserved a trend of reduction relative to controls (see Fig. 4).
To test whether the engineered vascular networks integrated with the host murine circulatory system, we next injected Angiosense 680 intravenously to enhance the contrast of perfused vessels.
In this study, using a murine model system, we have specifically determined the relative contribution of the liver, spleen, and bone marrow in the clearance of senescent neutrophils from the circulation under homeostatic conditions and examined the fate of senescent neutrophils that home back to the bone marrow.
To investigate the role of STAT1 in mammary tumorigenesis, we employed a novel murine system that provided mechanistic insights into the physiological consequence of loss of STAT1 expression.
Using murine model systems, we here demonstrate that TH positively regulates serum Se and selenoprotein P (Sepp) levels.
By combining human and murine experimental systems, we extend this concept by providing evidence for an MDSC-mediated mechanism by which fungi modulate host defense, orchestrated by Dectin-1/CARD9, ROS, caspase-8, and IL-1β.
We confirm that in a murine system cMSC proliferation in low serum is not affected by changing the glucose levels in the medium and show that Egr-1 does not seem to be involved in the proliferative response to glucose.
In order to further characterize the regulation of glucose metabolism in T lymphocytes, we decided to switch to the murine system.
However, we have found that in contrast to the murine system, endosomal trafficking of human CD1d molecules is not required to stimulate autoreactive responses from human NKT cells [31].
