A recent murine study showed that ficolin-B, the mouse orthologue of human M-ficolin, was stored in and released from immature granulocytic myeloid cells during sepsis [ 48].
A recent murine study showed that OX40 activation not only reversed effector T-cell hyporesponsiveness, but also negated Treg function leading to tumour rejection (Piconese et al, 2008).
A recent murine study showed that CO acts as a key molecule in successful pregnancy by modulating the uterine NK cells, which result in the promotion of the remodelling of maternal spiral arteries (Linzke et al., 2014).
49 Another murine study showed that in utero caloric restriction is associated with loci-specific hypomethylation in the male germline at differentially methylated regions that can partially survive reprogramming processes in early embryo development, with altered gene expression at discrete sites.
This is further supported by murine studies showing that administration of a Pam3CSK4 with OVA augmented Th2-associated cytokine production by antigen-specific T cells [35].
We noted that in murine studies, showing the most potent CpG effects, CpG is provided along with the antigen or in close proximity to tumor antigens [12], [18], [19], [20].
That DNA methylation is not critical to the developmental appearance of histone modifications is further supported by recent murine studies showing that differential histone modification of the Xs in early development precede differential developmental appearance of DNA methylation [ 33, 34].
The CD4+ phenotype of CI-specific T cells is consistent with murine studies showing that type II collagen-specific T cells in the collagen-induced arthritis mouse model also express a CD4+ phenotype and express high levels of Th1 cytokines [ 29].
Human and murine studies showed that GM-CSF exerts beneficial effects on intestinal inflammation.
This data from in vitro and murine studies shows that aldosterone might play a relevant role in adipocyte biology.
