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A recent murine study showed that ficolin-B, the mouse orthologue of human M-ficolin, was stored in and released from immature granulocytic myeloid cells during sepsis [ 48].
A recent murine study showed that OX40 activation not only reversed effector T-cell hyporesponsiveness, but also negated Treg function leading to tumour rejection (Piconese et al, 2008).
A recent murine study showed that CO acts as a key molecule in successful pregnancy by modulating the uterine NK cells, which result in the promotion of the remodelling of maternal spiral arteries (Linzke et al., 2014).
49 Another murine study showed that in utero caloric restriction is associated with loci-specific hypomethylation in the male germline at differentially methylated regions that can partially survive reprogramming processes in early embryo development, with altered gene expression at discrete sites.
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The net effect in this trial could be inhibition of imatinib metabolism, and this is supported by a murine study showing a 41% reduction in CYP3A4 activity after 8 weeks of cyclophosphamide treatment (Emmenegger et al, 2007).
Human and murine studies showed that GM-CSF exerts beneficial effects on intestinal inflammation.
These murine studies showed a clear anatomical contribution in erosion formation and prompted a close evaluation of human knee joints, to determine whether similar structures existed.
Further, murine studies showed that TLR4 functional mice are more protected against reinfection compared with mice with dysfunctional or absent TLR4 [ 36].
These murine studies showed that monocytes/macrophages in lupus probably have defects beyond abnormal phagocytosis and that these cells may take part in aberrant regulation of the immune system.
This is further supported by murine studies showing that administration of a Pam3CSK4 with OVA augmented Th2-associated cytokine production by antigen-specific T cells [35].
We noted that in murine studies, showing the most potent CpG effects, CpG is provided along with the antigen or in close proximity to tumor antigens [12], [18], [19], [20].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com